Choosing a spectroscopic technique: careful planning of measurements is important in the context of a specific experiment.Recent advances allow proton MRS without water suppression. This is achieved by adding water suppression pulses. Suppressing the water signal: because water molecules contain hydrogen, and the relative concentration of water to metabolite is about 10,000:1, the water signal is often suppressed or the metabolite peaks will not be discernible in the spectra.This step is usually automated but can be performed manually. Shimming the magnetic field: this step is taken to correct for the inhomogeneity of the magnetic field by tuning different pulses in the x, y, and z directions.MRS can be used to determine the relative concentrations and physical properties of a variety of biochemicals frequently referred to as "metabolites" due to their role in metabolism.Īcquiring an MRS scan is very similar to that of MRI with a few additional steps preceding data acquisition. As a result, MRI often uses the larger available signal to produce very clean 2D images, whereas MRS very frequently only acquires signal from a single localized region, referred to as a "voxel". Both techniques typically acquire signal from hydrogen protons (other endogenous nuclei such as those of Carbon, Nitrogen, and Phosphorus are also used), but MRI acquires signal primarily from protons which reside within water and fat, which are approximately a thousand times more abundant than the molecules detected with MRS. Magnetic resonance spectroscopy is an analytical technique that can be used to complement the more common magnetic resonance imaging (MRI) in the characterization of tissue. In the case of muscles, NMR is used to measure the intramyocellular lipids content (IMCL). It has also been used to study the metabolism of other organs such as muscles. Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a non-invasive, ionizing-radiation-free analytical technique that has been used to study metabolic changes in brain tumors, strokes, seizure disorders, Alzheimer's disease, depression, and other diseases affecting the brain. In vivo magnetic resonance spectroscopy ( MRS) is a specialized technique associated with magnetic resonance imaging (MRI). JSTOR ( May 2010) ( Learn how and when to remove this template message).Unsourced material may be challenged and removed.įind sources: "In vivo magnetic resonance spectroscopy" – news
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